MAP2 and Alzheimer disease: Of note, there was a significant decrease in MAP2 positive cells in the cortex of the AD-TBI group (47.20±11.00 neurons/ HPF) compared to the AD-Sham group (101.33±11.68 neurons/ HPF, p<0.01) and NT-Sham group (133.71±20.00 neurons/ HPF, p<0.01) (Figure 4B).