Circulating RBP4 levels have been shown to rise and to positively correlate with body mass index (BMI) [5], [6] and to be associated with insulin resistance [5]–[8], while there have been contrasting reports of similar RBP4 levels regardless of BMI and no significant correlation between RPB4 and insulin resistance [9]–[12]. The gene discussed is POLR2D; the disease is Insulin resistance.