ITGAM and rheumatoid arthritis: In addition, considering that RA is a systemic inflammatory disease, manifested locally as erosion of the joints, and that the pathogenesis of RA involves systemic-derived cellular infiltration and cytokine production [36], [37], it is possible that CD11b+ cells transfected by PEI/IL2/15Rβ siRNA particles in other places might migrate to inflamed joints to counterbalance local inflammation.