CCR6 and Immunodeficiency: In order to confirm that the phenotype observed in CCR6KO and CXCR3KO mice was specifically due to ablation of CCR6 and CXCR3 in T cells (not a general immune deficiency), CD4+ T cells from CCR6KO or CXCR3KO mice after DS were adoptively transferred to T cell-deficient RAG1KO mice.