Increased production of CXCR3 and CXCL-9, -10, and -11 have been observed in the ocular surface and increased frequency of CXCR3+ and CCR5+ T cells has been detected in draining lymph nodes of mice with experimental dry eye induced by subjecting them to desiccating stress (DS) [16], [17]. This evidence concerns the gene CXCR3 and dry eye syndrome.