Since previous work has shown that RhoB loss of expression through ovary cancer progression and many tumor suppressor genes are silenced by epigenetic modification in ovary cancinogenesis [24], RhoB expression in ovary carcinoma SKOV3 and A2780 cell lines was analyzed after treatment with 5-Aza and TSA to see if the expression silence can be effectively revived by either promoter histone deacetylation or methylation. This evidence concerns the gene RHOB and neoplasm.