Couderc et al. reported that in vitro reintroduction through recombinant adenovirus transduction could result in the apoptosis of endogenous RhoB low-expressing ovarian adenocarcinoma cells (OVCAR-3/IGROV-1) through the intrinsic apoptotic caspase cascade activation [36]. The gene discussed is RHOB; the disease is ovarian adenocarcinoma.