For example, Sampson et al. demonstrated that peptide vaccines targeting EGFR variant III (EGFRvIII), which is a constitutively activated and immunogenic mutation not expressed in normal tissues but widely expressed in glioblastoma multiforme (GBM), were capable of inducing potent T- and B-cell immunity in GBM patients, and successfully eliminated tumor cells which expressed the targeted antigen, leading to an unexpectedly long survival time without any evidence of symptomatic collateral toxicity [25]. This evidence concerns the gene EGFR and neoplasm.