Of note, the T790M-5 and T790M-7-specific T cell lines established in these NSCLC patients were functional, since they showed substantial cytokine production or cytotoxicity against the NSCLC cell lines that harbored both the EGFR-T790M mutation and HLA-A2 (data not shown). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.