Similarly, NgBR knockdown diminishes the estradiol-induced growth of T47D breast tumor cells (24 hour: NS: 7.95±0.550×104 cells vs NS+E2∶12.733±0.521×104 cells, n = 3, p<0.05; NS+E2∶12.733±0.521×104 cells vs siNgBR+E2∶9.777±0.665×104, n = 3, p<0.05). This evidence concerns the gene NUS1 and breast neoplasm.