Having demonstrated that DMBT1 is up-regulated by IL-22 and IL-27 [23] and given the increased expression of IL-22 and IL-27 in active IBD as shown by us and others [34], [35], [38], we next compared DMBT1 mRNA expression levels in all inflamed (n = 30 biopsies) and not inflamed (n = 45 biopsies) intestinal biopsies from the above described 27 CD patients. This evidence concerns the gene DMBT1 and inflammatory bowel disease.