As both most strongly IBD-associated DMBT1 SNPs rs2981745 and rs2981804 are located in non-coding regions of DMBT1 (rs2981745∶5′-untranslated region (UTR); rs2981804∶6th intron, Fig. 1A), we hypothesized that these SNPs might be located within DNA binding sequences of nuclear proteins. The gene discussed is DMBT1; the disease is inflammatory bowel disease.