At days 5, 8 and 13 post-infection (p.i.), the presence of HSV1-specific CD8+ T cells was evaluated on splenocytes by staining with MHC-peptide dextramers specific for the immunodominant SSI CTL epitope of glycoprotein B. As shown in Figure 2A, at day 5 p.i. low numbers of SSI-specific T cells were detected in both groups of mice. This evidence concerns the gene CD8A and infection.