Since SWT can treat climacteric syndrome and it significantly down-regulates TGF-β coding gene (one of the 2,045 differentially expressed genes, Table S3), we inferred that one of the therapeutic effects of SWT on osteoporosis and coronary heart disease could attribute to the down-regulation of TGF-β by SWT [30]. Here, TGFB1 is linked to osteoporosis.