Fig. 1A shows the experimental animal groups. Der p-stimulated mice that had been orally treated with XQLT (PAT and PAC; Fig. 1B) had fewer infiltrating cells in the BALF compared with the Der p-challenged mice without oral XQLT administration (DP; Fig. 1B). Further analysis showed that the oral administration of XQLT to mice, particularly as a pre-allergy treatment, reduced total IgE production (PAT; Fig. 1C). In addition, XQLT was demonstrated to reduce allergic inflammation, particularly when administered orally as a pre-allergy treatment (PAT; Fig. 1B and C). The gene discussed is IGHE; the disease is Allergy.