ERBB2 and breast cancer: A number of prognostic factors for NAC have been correlated with OS and disease free survival (DFS) in locally advanced breast cancer, such as the triple-negative type, the human epidermal growth factor receptor 2 (HER2)-enriched type (hormone receptor negative/HER2 positive type) (2,3), a pathological complete response (pCR) (4,5) and the number of involved axillary lymph nodes (ALNs) at surgical staging (6,7).