SOD1 and Hyperglycemia: Hyperglycemia causes an increased production of free radical which plays a major role in the disruption of the cellular functions of the kidney that correlates to a decline in the endogenous ROS scavengers such as GSH-px, SOD, GST and catalase (Kalia et al., 2004; Cameron et al., 2005; Jandeleit-Dahm et al., 2005).