In a case-control study upon 47 infants, lower MBL cord blood concentrations were associated with a higher incidence of Gram-negative sepsis (P = 0.036) [31], and an observational cohort study upon 100 pediatric ICU patients identified MBL2 gene exon 1 polymorphisms as a main determinant of progression from sepsis to septic shock [32]. The gene discussed is MBL2; the disease is Sepsis.