Kennedy et al. found that sinonasal ITACs have a distinctive phenotype, with all cases expressing CK20, CDX-2, and villin and most ITACs also expressing CK7, so that the expression pattern of CK7, CK20, CDX-2, and villin positive may be useful in separating these tumors from other non-ITAC adenocarcinomas of the sinonasal tract [43]. The gene discussed is CDX2; the disease is adenocarcinoma.