Although ectopic expression of human telomerase reverse transcriptase (hTERT) in normal human cells sufficed to immortalize the cells and enhanced the ability to induce neoplastic transformation [36], [37], and transgenic mice overexpressing TERT were prone to tumorigenesis [38], [39], inhibition of telomerase in cancer cells limited proliferation through telomere shortening and cell death [40], [41]. The gene discussed is TERT; the disease is cancer.