Importantly, in line with the in vitro data shown in Figure 3, proliferation of tumor cells was increased after BGN knock-down as evidenced by Ki67 staining compared to control (Ki67 positive area fraction in shBGN group 16.68 ± 2.1% and 7.18 ± 1.2% in scrambled shRNA control group, p=0.005, Figure 5D-F). Here, MKI67 is linked to neoplasm.