For example, miR-10a-5p as a vital modulator, could suppress the growth of chronic myeloid leukemia CD34+ cells [39], and miR-10b-5p targets the potent inflammatory mediator KLF4 (Kruppel-like factor 4) [40] and has important roles in tumor invasion and the initiation of metastasis in breast cancer [41]. The gene discussed is KLF4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.