Injection of BM cells from MM patients vs. healthy donor BM cells resulted in substantially higher hHLA-A,B,C, hCD45 and hCD138 positive cells, which was significant for hHLA-ABC+ and hCD138+ in the murine BM and for hHLA-A,B,C+ and hCD45+ cells in the spleen (p <0.005, one way ANOVA Figure 4C). The gene discussed is HFE; the disease is Miyoshi myopathy.