The APOE ε4 allele carriers excessively drop out from the stream of aging to 90 years old and over [5], while being overrepresented in aging-related pathologies, such as LOAD and cardiovascular diseases [39,40].  Similarly, the FOXO1A and FOXO3A variants, in addition to longevity [41], are also associated with diseases such as type 2 diabetes and stroke [42,43]. Here, FOXO1 is linked to type 2 diabetes mellitus.