After confirming ADAM17 as the protease responsible for processing TNF-α by CD8+ T cells, we investigated whether a lack of ADAM17 on CD8+ T cells modulated lung injury in our non-infectious, SPC-HA transgenic mouse model of influenza infection by adoptively transferring HA-specific ADAM17−/− CD8+ T cells into SPC-HA transgenic mice. Here, CD8A is linked to influenza.