In the present study, consistent with severer insulin resistance and hepatic lipid infiltration, elevated SREBP-1c mRNA and PERK, phospho-eIF2α and CHOP protein expressions concomitant with decreased GRP78 protein expressions were significantly induced by continuous feeding of high-fat diet enriched with lard oil in HL/HL group. The gene discussed is SREBF1; the disease is Insulin resistance.