It was previously demonstrated that the absence of Fhit protein in cancer cells resulted in resistance to paclitaxel [28]; Annexin 4, a protein with both plasma membrane and cytoplasmic localization, has been reported to be overexpressed in many cancer cells; in particular, it has been demonstrated that Annexin 4 over-expression contributes to cancer cells resistant to paclitaxel [29]. This evidence concerns the gene FHIT and cancer.