Interestingly, Fhit overexpression in Fhit-negative lung cancer cells prevents annexin A4 translocation from cytosol to cell membrane; furthermore, simultaneous treatment of A549 cancer cells with AdFHIT and paclitaxel is much more effective in triggering apoptosis of cancer cells compared to controls; similar results were obtained with the administration of paclitaxel to annexin A4-depleted A549 cells. The gene discussed is FHIT; the disease is lung carcinoma.