It was also reported that the serum IL-18 level in gastric cancer patient group was significantly higher than that in gastric ulcer patient group [25] and IL-18 can increase metastasis and immune escape of stomach cancer via the down-regulation of CD70 and maintenance of CD44 in human gastric cancer cell line NCI-N87 and SNU16 [26]. The gene discussed is IL18; the disease is gastric ulcer.