Therefore, the insulin levels at 120 minutes were remarkably higher in the patients with advanced hepatic fibrosis (F0 versus F2, P<0.05; F0 versus F3, P<0.01; F1 versus F2, P<0.01; F1 versus F3, P<0.01), as previously reported [24], [25]. This evidence concerns the gene INS and Hepatic fibrosis.