These effects of statins in favoring the accumulation of Treg in inflamed tissues were also observed in a model of atherosclerosis in apo lipoprotein E-deficient (ApoE−/−) mice, and simvastatin increased the expression of Foxp3, IL-10, and TGF-β in both the atherosclerotic plaque and in circulating cells. Here, FOXP3 is linked to atherosclerosis.