Forty-six percent of T2DM (n = 86) were hypogonadal, and in 82 of these patients (93%) LH and FSH levels were significantly lower when compared with patients with normal TT/cfT levels (3.5 ± 0.3 versus 7.3 ± 0.3 mIU/mL for LH and 5.8 ± 0.6 versus 9.2 ± 0.45 mIU/mL for FSH; P < 0.02), and only 4 men had testosterone, LH, and FSH concentrations characteristic to primary hypogonadism. Here, PLOD1 is linked to Hypergonadotropic hypogonadism.