Cai et al. [6] used a model of acute ischemic stroke induced by middle cerebral ischemic/reperfusion in rats and demonstrated that BHD successfully improved the neurological deficits, ameliorated the cerebral infarction, stimulate neural proliferation, and enhanced the expression of vascular endothelial growth factor (VEGF) and its receptors, which were useful for the recovery of neurological functions after ischemic stroke. Here, VEGFA is linked to ischemic stroke.