We report a case of 48-year-old man with a diagnosis of HIV infection since 1993, on HAART (abacavir, lopinavir-ritonavir, and stavudine) with a recent CD4 count of 692, and undetectable viral load for years type II diabetes, and generalized tonic-clonic, complex partial and motor seizures since childhood. This evidence concerns the gene CD4 and HIV infectious disease.