X. Li and colleagues (“The rs1142345 in TPMT affects the therapeutic effect of traditional hypoglycemic herbs in prediabetes”) concluded that a single nucleotide polymorphism (rs1142345) in thiopurine S-methyltransferase could affect the therapeutic outcome of the patients with T2DM receiving the TCM, Tianqi Jiang Tang. Here, TPMT is linked to prediabetes syndrome.