Another study by C. L.-T Chang et al. (“Antidiabetic effect and mode of action of cytopiloyne”) reported that a small molecule, cytopiloyne, isolated from Bidens pilosa, improved type 2 diabetes (T2DM) in db/db mice via its modulation of β-cell functions (insulin production and β-cell preservation) involving the calcium/DAG/PKCα cascade. The gene discussed is INS; the disease is type 2 diabetes mellitus.