Studies have shown that many proinflammatory cytokines and mediators such as macrophage colony-stimulating factor (M-CSF), the receptor activator of nuclear factor κB ligand (RANKL), TNF, IL-1, and IL-17 play dominant roles in the pathogenesis of arthritis-associated bone loss [1, 3]. The gene discussed is TNFSF11; the disease is Arthritis.