In the subgroup analysis by ethnicity, the results revealed a significant association between the cyclin D1 G870A polymorphism and NPC in Caucasian population (A versus G: OR = 0.754, 95% CI = 0.589–0.967, P = 0.026, Phet = 0.989; homozygote comparison model AA versus GG: OR = 0.524, 95% CI = 0.317–0.865, P = 0.011, Phet = 0.968; heterozygote comparison model GA versus GG: OR = 0.467, 95% CI = 0.299–0.730, P = 0.001, Phet = 0.730; dominant model GA + AA versus GG: OR = 0.487, 95% CI = 0.319–0.741, P = 0.001, Phet = 0.804). This evidence concerns the gene CCND1 and nasopharyngeal carcinoma.