This Zn-curc complex might be useful in developing efficient anticancer drugs becuase (i) its ability to target one of the most common p53 mis-sense mutant, that is R1775H (http://www-p53.iarc.fr), (ii) its cytotoxic effect specific for tumor cells, and (iii) its capacity to cross the BTB when systematically administered. The gene discussed is TP53; the disease is neoplasm.