TP53 and neoplasm: Interestingly, we recently demonstrated that zinc supplementation is required for the drug-induced immunogenic cell death in chemoresistant p53-functionally defective cancer cells [37] centering the 2 ideal goals of anticancer therapy that are the induction of a strong cytotoxic response of tumor cells [38] and the stimulation of host tumor-specific response, cooperating in the achievement of clinically relevant effects [39].