Our previous characterization of the nuclear BET protein interactome had identified an interaction between BRD4 and a proportion of WT NPM1 with three separate proteomic methodologies in HL60 cells.6 We could further document that a portion of BRD4 colocalizes with WT NPM1 in primary samples from AML patients (Supplementary Figure 4). This evidence concerns the gene DNER and acute myeloid leukemia.