As an exemplar of this principle, we and others have recently shown the efficacy and mechanism of action of protein–protein interaction inhibitors of the bromodomain and extra-terminal (BET) family of epigenetic readers in animal models of mixed lineage leukemia (MLL)-rearranged leukemias,6, 7 multiple myeloma8 and non-Hodgkins lymphoma.9 However, the efficacy and potential mechanism(s) of action of BET inhibitors in other forms of AML are largely unknown. This evidence concerns the gene DNER and acute myeloid leukemia.