These data demonstrate that in addition to cell lines harboring MLL translocations, a number of AML cell lines including OCI-AML3 (which is the only human cell line that contains an NPM1c mutation), KG-1 (FGFR1OP2-FGFR1 rearrangement), SKM1 (EZH2 Y641C mutation), Kasumi (AML1-ETO rearrangement) and ME-1 (CBFβ-MYH11 rearrangement) show sensitivity to treatment with I-BET, both in liquid culture and clonogenic assays (Figures 1a and b and data not shown). The gene discussed is SCN4A; the disease is acute myeloid leukemia.