In this context, it is also important to note that pharmacological inhibition of PKD activity has been shown not to attenuate cardiac hypertrophy in different models in the rat in vivo [45], although cardiac-specific deletion of PKD1 in the mouse significantly inhibited cardiac hypertrophy in response to TAC or chronic isoproterenol infusion [15]. The gene discussed is PRKD1; the disease is cardiac hypertrophy.