Since hyperglycemia has also been listed as a growing risk factor for PD (Hu et al. 2007; Jagota et al. 2012; Sun et al. 2012), we focused our study on the neuroprotective effect of RESV on HG-induced oxidative stress and apoptosis in DAergic PC12 cells with regard to GRP75 and p53 localization. This evidence concerns the gene TP53 and Hyperglycemia.