Furthermore, a previous study described a specific recurrent chromosomal break region at the chromosome 2q24–2q32 region encompassing the TANK-encoding locus,41 extensive characterizations of GBM genomes failed to identify frequent gene rearrangements in the TANK-containing region.42 GBMs often show hypoxic areas with low availability of oxygen,43 raising the possibility that this could contribute to the regulation of TANK abundance. Here, TANK is linked to glioblastoma.