Gender and CD4 count are recognized risks for NVP HSR (20), and we have also observed significant associations with human leukocyte antigen (HLA)-C*04:01 genotype and predisposition to NVP cutaneous reactions, namely, SJS/TEN, in this cohort (n = 117 hypersensitive versus n = 154 tolerant patients) (21). The gene discussed is CD4; the disease is toxic epidermal necrolysis.