For patients with mitral insufficiency, an increased BNP level was correlated with mortality and the onset of congestive heart failure, regardless of the degree of regurgitation present on echocardiography, suggesting that BNP is a reflection of its atrial and ventricular consequences.2 Finally, it was proven that NT-pro-BNP was correlated with symptoms and echocardiographic severity of mitral stenosis.2 In addition, the levels of BNP were increased in patients with pulmonary embolism and pulmonary hypertension.2 This evidence concerns the gene NPPB and pulmonary arterial hypertension.