PINK1 and Parkinson disease: For instance, RNAi-mediated loss of endogenous PINK1 and DJ-1 elicit robust dynamin related protein 1 (Drp-1)-mediated mitochondrial fission, increased mitochondrial ROS, mitochondrial dysfunction, and dysregulated autophagy in neurons suggesting that both PD genes are critical for maintaining mitochondrial and autophagic homeostasis.