More recently, inhibition of SREBP-1 has been shown to markedly reduce the levels of unsaturated fatty acids by downregulating stearoyl-CoA desaturase 1 (SCD1), a key enzyme to catalyze saturated fatty acid to mono-unsaturated fatty acid (Figure 1), thus increasing the ratio of saturated- to unsaturated-fatty acids and leading to lipotoxicity in GBM cells [33,114]. Here, SREBF1 is linked to glioblastoma.