TP53 and colorectal carcinoma: Overall, CRC-specific hypermethylation affects WNT, receptor tyrosine kinase, neurogenic locus notch homolog protein (NOTCH), TP53, PI3K, retinoic acid and IGF signaling, as well as other signaling pathways that regulate cell cycle, transcription, DNA repair/stability, apoptosis, adhesion, angiogenesis, invasion and metastasis [83,90,91,92,93,94,123].