Multiple class I HDACs are up-regulated in a subset of CRCs, including HDAC1 in 36.4%, HDAC2 in 57.9%, and HDAC3 in 72.9% of CRC specimens, and high HDAC expression has been shown to be associated with reduced patient survival in CRC [163]. The gene discussed is HDAC2; the disease is colorectal carcinoma.