At present, the Src tyrosine kinase inhibitor AZD0530 (saracatinib), a Src inhibitor for c-Src and v-Abl, is being investigated in a phase II clinical trial in lung metastatic osteosarcoma with complete metastasectomy by the Sarcoma Alliance Research through the Collaboration Global Cooperative Network (SARC012, NCT00752206). This evidence concerns the gene SRC and osteosarcoma.