CDKN2A and Miyoshi myopathy: Moreover, methylation of several of these genes was associated with poor prognosis of MM patients and include SPARC, BNIP3 [50], DAPK, RARβ [51], EGLN3 [52], DLC-1 [53], CDH-1 [54], DCC, TGFβR2 [55], CD9 [56] and p16 [57].