Since loss of histone acetylation seems to be a mark of ZEB1 induction, we treated three NSCLC cell lines with vorinostat (SAHA), a HDAC inhibitor, either alone or in combination with 5-aza-2'-deoxycytidine (AZA), an inhibitor of DNA methylation. The gene discussed is ZEB1; the disease is non-small cell lung carcinoma.