PDGFRA and Ewing sarcoma: In that system, category one sarcomas, consist of non-pleomorphic tumors with pathogenomic molecular events, e.g., gastrointestinal stromal tumors, KIT or platelet-derived growth factor receptor, alpha polypeptide (PDGFRA) mutations; dermatofibrosarcoma protuberans, t(17;22)(q22;q13), ring chromosomal alterations, involved genes COL1A1-PDGFRB; and Ewing’s sarcoma, chromosomal translocation t(11:22; q24; q12), in 85% of cases, involved genes FLI1-EWS.