For example, the chemical carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) induces activating mutations in H-ras, and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), an inflammation irritator, expands H-Ras-targeted cells and elicits skin inflammation. Here, HRAS is linked to neoplasm.