Alterations in DNA mismatch repair genes, such as MLH1 and MSH2, are associated with the Lynch syndrome (formerly known as hereditary non-polyposis colorectal cancer or HNPCC), which is characterized with increases in not only colorectal cancer but also ovarian, endometrium, liver, skin, brain, and gastric cancer [204]. This evidence concerns the gene MSH2 and hereditary nonpolyposis colon cancer.