However, a subsequent study demonstrated that the incidence of pre-neoplastic and invasive gastric carcinomas was decreased in p53 hemizygous mice [21], and an independent group reported that no differences in gastric apoptotic or proliferation indices between p53+/+ and p53+/– mice after infection with H. pylori SS1 strain [208]. The gene discussed is TP53; the disease is gastric carcinoma.