Song et al. reported that in gastric cancer, HIF-1α, but not HIF-2α, enhances the expressions of glucose metabolism-related genes such as ENO1, pyruvate kinase 2 (PKM2), phosphoglycerate kinase 1 (PGK1), GLUT1 and LDHA in response to hypoxia [12]. This evidence concerns the gene PGK1 and gastric cancer.