A meta-analysis of the effects of fish oil supplementation on the inflammatory markers of patients with chronic heart failure showed that circulating TNFα, IL-1, and IL-6 (proinflammatory cytokines) decreased after a supplementation period of 3 to 12 months with an EPA and DHA dose of 600 to 5,540 mg/day. This evidence concerns the gene IL6 and congestive heart failure.